The Department of Economics Theory, History and Development Seminar Series presents
“Molecular Genetics of Economic Decision Making”
with Chew Soo Hong and Richard P. Ebstein, National University of Singapore
Friday, October 28, 2011
Social Science Plaza B, Room 3266 (Econ Library)
The study of decision making lies at the heart of economics and much of the social sciences. The speakers report the results of several studies to seek a deeper understanding of economic decision making at the level of molecular genetics. Specific findings under social decision making include altruistic giving in a Dictator Game being linked to the arginine vasopressin 1a receptor (AVPR1a) and fairness preferences in the Ultimatum Game being jointly associated with gene (DRD4) x environment (season-of-birth) and that gender difference in fairness preference is further linked to sex-hormone genes. For individual decision making, the speakers have developed a neurochemistry-based model of a reference-dependent valuation function together with a reference-dependent saliency function that links neurochemical properties at the gene level to observable risky choice. This was tested in two studies. One links attitude towards even-chance risks over gains and over losses to a dopamine polymorphism DAT1 and a serotonergic polymorphism STin2 and another links attitude towards longshot risks to the monoamine oxidase A (MAOA) gene. They further carried out a genome-wide-association (GWA) study of 1800 Han Chinese subjects from Singapore (~1100) and Beijing (~700) who participated in incentivized laboratory experiments on individual and social decision making and were inventoried for personality traits, facets of social cognition, and religious-spiritual orientation, and identified specific genes at GWA significance (p
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